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UAM (Universidad Autónoma de Madrid)

UAM (Universidad Autónoma de Madrid)

La Universidad Autónoma de Madrid es una universidad pública española, ubicada en Madrid y fundada en 1968, momento en que sus facultades estaban dispersas por diversos edificios de la capital española. En junio de 2018 la Universidad Autónoma de Madrid cumplirá sus primeros 50 años. Para celebrar este aniversario, la universidad prepara un programa conmemorativo que se desarrollará entre los años 2016 y 2019 e incluirá actividades abiertas a todo el conjunto de la sociedad. https://www.uam.es/

Reconstrucciones cuantitativas en 3D de la ultraestructura de las sinapsis

Fuente: UAM Gazette | Publicado: 02-11-2017
Neurocientíficos de la Universidad Autónoma de Madrid han conseguido medir por primera vez la estructura tridimensional de los contactos intercelulares que permiten que la información de los sentidos ‘entre’ a la corteza cerebral. El estudio se publica en la revista Cerebral Cortex y está adscrito al proyecto europeo The Human Brain Project.
Derechos: Reconstrucción 3D de las sinapsis. UAM.
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Investigadores del Departamento de Anatomía, Histología y Neurociencia de la Facultad de Medicina de la Universidad Autónoma de Madrid (UAM) han conseguido medir los parámetros estructurales fundamentales de las sinapsis existentes entre los axones de las neuronas del tálamo y las de la corteza cerebral.


Este es un significativo avance, tanto técnico como conceptual, para comprender cómo el ‘hardware celular’ contribuye a crear orden jerárquico en el flujo de información a través de las redes neuronales del cerebro.



“Concretamente, hemos descubierto especializaciones estructurales que podrían explicar por qué estas sinapsis en particular tienen tal potencia funcional que, pese a su pequeño numero relativo, imponen su ritmo de actividad eléctrica y su campo receptivo a las neuronas de la corteza cerebral a las que inervan, haciendo así que, por ejemplo, una determinada región de la corteza cerebral se dedique a procesar selectivamente información táctil, o visual, etc.”, asegura el catedrático de anatomía Francisco Clascá, director del trabajo.


“Los parámetros que se han logrado medir son, además, un dato valioso para el desarrollo de modelos computacionales avanzados del funcionamiento de los circuitos del cerebro”, agrega el profesor.


Durante los tres años en los que se llevó a cabo el trabajo, los investigadores se valieron de técnicas de marcado selectivo a larga distancia de axones en el cerebro de ratones. Estas las combinaron con técnicas avanzadas de microscopía electrónica tridimensional (S-TEM y FIB/SEM) para visualizar y medir con precisión las diminutas estructuras subcelulares.


El estudio, que se publica ahora en la revista Cerebral Cortex, contó con la colaboración de investigadores del Instituto de Neurociencia y Medicina del Forschungszentrum Julich (Alemania) y del Laboratorio de Circuitos Corticales de la Universidad Politécnica de Madrid, y se ha realizado en el ámbito del proyecto internacional The Human Brain Project, financiado por la Unión Europea.


Referencia bibliográfica: Rodríguez-Moreno J. y cols. Quantitative 3D Ultrastructure of Thalamocortical Synapses from the “Lemniscal” Ventral Posteromedial Nucleus in Mouse Barrel Cortex, Cerebral Cortex. Doi: 10.1093/cercor/bhx187
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