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La Agencia Estatal Consejo Superior de Investigaciones Científicas (CSIC) es la mayor institución pública dedicada a la investigación en España y la tercera de Europa. Adscrita al Ministerio de Economía y Competitividad, a través de la Secretaría de Estado de Investigación, Desarrollo e Innovación, su objetivo fundamental es desarrollar y promover investigaciones en beneficio del progreso científico y tecnológico, para lo cual está abierta a la colaboración con entidades españolas y extranjeras. El CSIC desempeña un papel central en la política científica y tecnológica, ya que abarca desde la investigación básica a la transferencia del conocimiento al sector productivo. El motor de la investigación lo forman sus centros e institutos, distribuidos por todas las comunidades autónomas, y sus más de 15.000 trabajadores, de los cuales más de 3.000 son investigadores en plantilla y otros tantos doctores y científicos en formación. El CSIC cuenta con el 6 por ciento del personal dedicado a la Investigación y el Desarrollo en España, que genera aproximadamente el 20 por ciento de la producción científica nacional. Además, gestiona un conjunto de importantes infraestructuras, la red más completa y extensa de bibliotecas especializadas y cuenta con unidades mixtas de investigación. http://www.csic.es/

Investigadores españoles descubren un proceso que previene la muerte neuronal provocada por enfermedades como el ictus, la epilepsia o el Alzheimer

Fuente: CIBERNED | Publicado: 22-01-2018
Investigadores del CSIC, la Universidad Autónoma de Madrid y CIBERNED (Centro de Investigación en Red de Enfermedades Neurodegenerativas) han descubierto un mecanismo que protege a las neuronas del daño provocado por el ictus o infarto cerebral, o por otras enfermedades neurodegenerativas como el Alzheimer, el Parkinson o la epilepsia. El mecanismo también actúa en células cancerígenas, aunque con efectos patológicos. El trabajo, fruto de la colaboración entre instituciones españolas y otras de Alemania y el Reino Unido abre la posibilidad de novedosos desarrollos en fármacos y terapias.
Derechos: Comparativas de neuronas: La imagen de la izquierda muestra neuronas muertas por estímulos neurotóxicos y la de la derecha muestra neuronas que sobreviven al estímulo neurotóxico en presencia de la proteína PKD.
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En el ictus o infarto cerebral y en enfermedades neurodegenerativas como la epilepsia, el Alzheimer, el Parkinson, la esclerosis lateral amiotrófica (ELA) o la esclerosis múltiple, un mecanismo conocido como excitoxicidad actúa directamente sobre las neuronas, provocando su muerte. Las neuronas, que sufren oxidación como resultado natural del envejecimiento, tienen mecanismos de resistencia que les permiten sobrevivir y continuar funcionando a lo largo de la vida de una persona. Estos mecanismos desaparecen en un cerebro que ha sufrido daños agudos, como los producidos por el ictus, o pierden paulatinamente efectividad en enfermedades como el Alzheimer. Con la desaparición o deterioro del mecanismo, las neuronas quedan desprotegidas y expuestas a daños irreversibles.



Los investigadores del CSIC, CIBERNED y la UAM han descubierto, por un lado, que la proteína kinasa D (PKD), es clave en la supervivencia neuronal, porque la excitoxicidad actúa directamente sobre ella, desactivándola. Por otro lado, han diseñado una forma mutada de la PKD, que genera un nivel muy alto de protección para las neuronas haciéndolas más resistentes a la oxidación patológica.


El trabajo, publicado recientemente en la prestigiosa revista Nature Communications, constituye un hito científico en la comprensión de los procesos patológicos neuronales. No obstante, como incide la Dra. Teresa Iglesias, directora del grupo “Nuevas Dianas en Neurodegeneración y Neuroprotección” en CIBERNED y en el Instituto de Investigaciones Biomédicas “Alberto Sols” de Madrid, e investigadora principal del proyecto, “es necesaria la cautela, y los fármacos y terapias dirigidas a proteger o potenciar el efecto neuroprotector de la PKD deberán ser altamente selectivos para evitar estimular la supervivencia no deseada de otro tipo de células”. “Esta proteína, que ayuda a la supervivencia neuronal, está muy potenciada en células cancerosas y favorece su crecimiento desmedido”, explica Iglesias. Así, el uso de fármacos que inhiban la proteína podría ser muy eficaz en tratamientos antitumorales y, al mismo tiempo, promover un deterioro neuronal.


El descubrimiento del mecanismo y el desarrollo por parte del grupo de Iglesias de la proteína “de diseño” abren la puerta a terapias que permitirán ralentizar la pérdida neuronal que ocurre con el envejecimiento o en enfermedades neurodegenerativas como el Alzheimer, que afecta a unos 35 millones de personas en el mundo y constituye un problema social y de salud, tanto por las consecuencias para los pacientes y sus familias como por los crecientes costos para los sistemas de salud.


 

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