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IDIBELL (Instituto de Investigación Biomédica de Bellvitge)

IDIBELL (Instituto de Investigación Biomédica de Bellvitge)

Centro de investigación en medicina celular. El IDIBELL es un centro de investigación en medicina celular, donde la investigación básica de alto nivel está al servicio de preguntas clínicas relevantes y del desarrollo económico. El IDIBELL es una fundación creada el año 2004, a partir de la fusión de varias entidades de investigación, participado por el Hospital Universitario de Bellvitge, el Instituto Catalán de Oncología y la Universidad de Barcelona. El Instituto está situado en espacio Biopol'H. El año 2009 se convirtió en uno de los cinco primeros centros de investigación españoles acreditados como instituto de investigación sanitaria por el Instituto de Salud Carlos III. El Instituto de Investigación Biomédica de Bellvitge está situado en el municipio de L’Hospitalet de Llobregat, al sur de Barcelona. Sus instalaciones están distribuidas entre el Hospital Duran i Reynals, el Hospital Universitario de Bellvitge y los edificios del campus de la Universidad de Barcelona de Bellvitge, en el espacio Biopol. Un aspecto fundamental de la investigación del IDIBELL es su proximidad al enfermo. Por su situación y por la actividad asistencial diaria que muchos de ellos desarrollan, los investigadores del IDIBELL conocen los problemas que son realmente prioritarios y qué soluciones resultan efectivas en la práctica clínica diaria. Institut d'Investigació Biomédica de Bellvitge (IDIBELL). Hospital Duran i Reynals. 3a planta - Gran Via de l'Hospitalet, 199. 08908 Hospitalet de Llobregat. Barcelona - Spain. Tel +34 93 260 74 11. info@idibell.cat

Investigadores IDIBELL-ICO identifican una nueva diana terapéutica para combatir la metástasis en cáncer de ovario

Fuente: IDIBELL | Publicado: 24-01-2018
Investigadores del Grupo de Señalización Molecular en Cáncer del Programa Oncobell del Instituto de Investigación Biomédica de Bellvitge (IDIBELL)- Programa ProCURE del Instituto Catalán de Oncología (ICO) han identificado un receptor celular clave en los procesos de metástasis en cáncer de ovario.
Derechos: El equipo investigador.
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Investigadores del Grupo de Señalización Molecular en Cáncer del Programa Oncobell del IDIBELL- Programa ProCURE del Instituto Catalán de Oncología (ICO) han identificado un receptor celular clave en los procesos de metástasis en cáncer de ovario. El hallazgo, publicado en Molecular Cancer Therapeutics, da pie a la utilización de inhibidores de este receptor como diana terapéutica en las variantes más agresivas de la enfermedad.



En el trabajo del equipo de investigación IDIBELL-ICO se ha conseguido asociar la expresión del receptor CXCR4 en células tumorales de ovario a su potencial de diseminación a través del torrente sanguíneo. CXCR4 es un receptor implicado en el movimiento de las células de la sangre, especialmente en aquellas ubicadas en la médula ósea, que ya había sido relacionado anteriormente con procesos de diseminación en cáncer de mama.


En estudios en modelos ortotópicos los investigadores demostraron que la administración de inhibidores de CXCR4 en aquellos cánceres donde previamente se había detectado la expresión elevada de este receptor, impedía en gran medida la propagación de las células tumorales a nivel sanguíneo y dentro del peritoneo. Paralelamente, también han observado que la eliminación genética de CXCR4 en cultivo celular da lugar a tumores de crecimiento más lento y más bajo porcentaje de diseminación.



El diagnóstico del cáncer de ovario se suele hacer tarde; en el 80% de los casos, los pacientes ya presentan metástasis o diseminaciones peritoneales que los pueden afectar a otros órganos vitales como el estómago, riñón, pulmón, etc. Por otra parte, si bien es cierto que la combinación de cirugía y quimioterapia con derivados del platino funciona muy bien, el porcentaje de recurrencia de la enfermedad a los dos años es del 70%.


Los investigadores consideran que el estudio de cómo las células tumorales diseminan es básico de cara a entender y mejorar el pronóstico de la enfermedad. Su línea de investigación se centra en identificar las moléculas implicadas en esta diseminación, que suele ir acompañada de una acumulación de líquido en la zona del peritoneo (ascitis), y se termina propagando a nivel de torrente sanguíneo. “Si identificamos los factores que impulsan el movimiento de las células tumorales en estas zonas, podemos intentar bloquearlos para minimizar las posibilidades de metástasis”, comenta la Dra. Agnès Figueras, primera autora del estudio.


Artículo de referencia: http://mct.aacrjournals.org/content/early/2017/11/15/1535-7163.MCT-17-0643
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