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UV (Universidad de Valencia)

UV (Universidad de Valencia)

La Universitat de València de hoy es el resultado de más de cinco siglos de historia que han permitido acumular unos saberes y unos tesoros documentales únicos, y que la han convertido en una de las mejores universidades españolas. Desde el siglo XIII se impartían en la ciudad de Valencia estudios superiores, pues en 1245 el rey Jaume I había obtenido del papa Inocencio IV la institución de un Studium Generale. Sin embargo, no fue hasta el 30 de octubre de 1499 cuando los jurados de la ciudad de Valencia redactaron las Constitucions de lo que iba a ser la primera Universitat de València, una institución autorizada por la Bula del 23 de enero de 1501, firmada por el papa valenciano Alejandro VI, y por el privilegio real de Fernando II el Católico, concedido el 16 de febrero de 1502. A lo largo de más de quinientos años, el desarrollo de la Universitat de València ha corrido en paralelo al crecimiento de la ciudad, y ha formado una parte inextricable de su trama urbana, generando espacios para la docencia, la investigación, la creación y difusión de cultura y ciencia, así como para la transferencia de conocimiento. http://www.uv.es/

No existe neurogénesis adulta en el hipocampo humano

Fuente: UV | Publicado: 08-03-2018
La generación de nuevas neuronas en el hipocampo humano desciende bruscamente en los niños hasta niveles indetectables en adultos. Se puede afirmar, por tanto, que la neurogénesis hipocampal adulta es prácticamente inexistente, al contrario de lo que se ha pensado en las últimas décadas. Un reciente trabajo desarrollado por el equipo del neurobiólogo de la Universitat de València José Manuel García Verdugo, en colaboración internacional con los laboratorios de los científicos Arturo Alvarez-Buylla (Universidad de California, San Francisco) y Zhengang Yang (Universidad de Fudan, Shangai), así lo defiende. El trabajo aparece publicado en la revista Nature.
Derechos: El equipo del Prof. García Verdugo.
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Durante años, numerosas investigaciones han demostrado que la zona subgranular del giro dentado del hipocampo de ciertos mamíferos –área relacionada con los procesos de memoria y aprendizaje– continúa generando nuevas neuronas en el cerebro adulto. Si bien existen estudios que extrapolan estos datos al hipocampo humano adulto, el trabajo que ahora publica Nature obtiene resultados muy distintos.

Tras realizar un amplio estudio de la capacidad neurogénica del hipocampo humano en muestras de distintas edades –desde el desarrollo fetal y lactante hasta las etapas adultas–, los resultados muestran que el número de progenitores proliferativos y nuevas neuronas en el giro dentado disminuye drásticamente durante el primer año de vida.

Algo parecido ocurre, según el estudio, con la capacidad proliferativa del giro dentado del primate no-humano Macaca mulatta. Los análisis muestran que durante los primeros estadios post natales existe generación de nuevas neuronas, pero ésta se ve muy disminuida durante el desarrollo juvenil.



“La generación de nuevas neuronas en el hipocampo humano y de primates no humanos se produce fundamentalmente en etapas embrionarias y de forma escasa en periodos post-natales, durante los primeros meses de vida”, asegura José Manuel García Verdugo, co-investigador principal del proyecto e investigador del Instituto Cavanilles de Biodiversidad y Biología Evolutiva, en el Parc Científic de la Universitat de València. “Apenas hemos podido observar algunas neuronas nuevas aisladas a los 7 y 13 años de edad, y ninguna en el caso de estudios realizados con pacientes adultos afectados de epilepsia”. Los análisis se han realizado en colaboración con el equipo de Neurocirugía Funcional del Hospital Universitario y Politécnico La Fe de Valencia y de su responsable, el neurocirujano Antonio Gutiérrez.


Estos datos contrastan con la amplia neurogénesis que tiene lugar en el hipocampo de otros mamíferos más primitivos, los roedores, modelo de estudio para miles de resultados de investigación.



“A diferencia de los roedores, los humanos nacemos con prácticamente todas las neuronas necesarias para el desarrollo normal, y este trabajo apunta a que las modificaciones y tratamientos futuros deben basarse en la plasticidad”, asegura García Verdugo´. La neuroplasticidad o plasticidad sináptica hace referencia a la comunicación que se establece entre neuronas, una propiedad que interviene para modular la percepción de los estímulos del medio, también relacionados hasta hoy con la neurogénesis.


No es la primera vez que aparecen diferencias en el desarrollo del cerebro humano con respecto a otras especies de mamíferos. “Uno de los grandes saltos evolutivos del ser humano es la existencia de corrientes de nuevas neuronas hacia nuestra corteza prefrontal en los lactantes, algo que no ocurre en ratones y que, además de guardar relación con la memoria y el aprendizaje, se vincula a la actividad social humana”.

En el caso del hipocampo, los resultados de este trabajo sugieren ahora la posible implicación de otros mecanismos de plasticidad del giro dentado humano adulto en los procesos de aprendizaje y memoria. “Más que de nuevas neuronas, habrá que comenzar a hablar de nuevos circuitos neuronales”, concluye el científico.

Este proyecto ha sido financiado por el Ministerio de Economía y Competitividad y por las ayudas a la investigación PROMETEO de la Generalitat Valenciana.


Referencia: Nature. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults Shawn F. Sorrells1,2, Mercedes F. Paredes1,3, Arantxa Cebrian-Silla4, Kadellyn Sandoval1,3, Dashi Qi5, Kevin W. Kelley1, David James1, Simone Mayer1,3, Julia Chang6, Kurtis I. Auguste2, Edward F. Chang2, Antonio J. Gutierrez7,
Arnold R. Kriegstein1,3, Gary W. Mathern8,9, Michael C. oldham1,2, Eric J. huang10, Jose Manuel Garcia-Verdugo4, Zhengang Yang5 & Arturo Alvarez-Buylla1,2
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