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UPV (Universidad del País Vasco)

UPV (Universidad del País Vasco)

La Universidad del País Vasco/ Euskal Herriko Unibertsitatea es el fruto de una larga hilera de tentativas, prodigadas a lo largo de la historia, para que el País Vasco contara con una universidad que diera respuesta a las múltiples necesidades que afloran en una sociedad dinámica y moderna. Adquiere su actual carta de naturaleza en 1980, sobre el precedente de la antigua Universidad de Bilbao e inspirándose en la Universidad Vasca de 1936. Adopta un emblema diseñado por Eduardo Chillida e incorpora al mismo un célebre verso de Iparragirre -Eman ta zabal zazu- que alude a la vocación universal de la cultura vasca. Hoy la UPV/EHU muestra una realidad pujante. Compuesta por más de 50.000 personas, es responsable del 70% de la investigación que se desarrolla en Euskadi y ha generado ya un cuarto de millón de titulados en las más diversas áreas del saber. Distribuida en tres campus -uno por cada uno de los territorios históricos de la actual Comunidad Autónoma Vasca- que agrupan a 32 facultades y escuelas, la UPV/EHU realiza una contribución decisiva a la realidad del País Vasco, hasta el punto de que éste sería hoy inconcebible sin el aporte diario de esta institución y sin el rico e intenso debate intelectual que se genera a su alrededor. http://www.ehu.eus

Desarrollan una revolucionaria técnica de microscopía que permite visualizar todas las células de una región cerebral

Fuente: UPV | Publicado: 12-03-2018
Un grupo interdisciplinar de físicos y biólogos que trabajan en la investigación de las células cerebrales ha concebido una nueva y revolucionaria técnica de microscopía que, por primera vez, permite obtener imágenes de todas las células dentro de un área determinada del tejido cerebral vivo. Su principal valor es que permite obtener imágenes de todas las células vivas no etiquetadas en un área cerebral determinada, cosa que hasta ahora era imposible. Este avance científico es fruto de la colaboración entre grupos de investigación de la Universidad de Burdeos y de la UPV/EHU y el centro ACHUCARRO de Leioa. La microscopía es uno de los métodos más utilizados en la neurociencia. Esta nueva técnica permitirá mejorar sustancialmente la información que obtenemos y con ello expandir el conocimiento de la biología del cerebro.
Derechos: Imagen de la neurona etiquetada en amarillo, rodeada de neuronas no marcadas (aparecen en blanco), utilizando la técnica SUSHI. Sin esta técnica, las neuronas que aparecen en blanco no se verían. © Jan Tønnesen & Valentin Nägerl.
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La microscopía es una herramienta básica en la investigación de la biología de cualquier organismo, dado que los elementos que se estudian, las células, tienen un tamaño microscópico y muchas veces, nanoscópico.



Hasta el momento, los métodos de microscopía existentes para investigar el tejido cerebral vivo se limitaban a visualizar sólo las células previamente marcadas. Sin embargo, por limitaciones técnicas, no todas las células en una región cerebral determinada podían etiquetarse simultáneamente, lo que ha restringido la visión, y por tanto, la comprensión que tenemos sobre cómo las células cerebrales, que están altamente interconectadas, se organizan e interactúan.


El Dr. Jan Tønnesen (Suecia, 1977), investigador del Programa Ramón y Cajal en el Departamento de Neurociencias de la UPV/EHU, y que trabaja en el centro ACHUCARRO (Achucarro Basque Center for Neuroscience) de Leioa es una de las personas que firman un trabajo que acaba de publicar la prestigiosa revista científica “CELL”, y en el que describen una nueva técnica de microscopía, denominada “SUSHI”, para mejorar la visualización de las células en tejido cerebral vivo.


La nueva técnica SUSHI (acrónimo de su nombre en inglés “Super-resolution Shadow Imaging”) permite etiquetar de una pasada el minúsculo espacio, lleno de líquido, que rodea las células cerebrales, evitando tener que etiquetar individualmente todas las células que se quieren analizar.



Dado que además esta “etiqueta” permanece fuera de las células, produce una especie de imagen en negativo, que podemos asemejar a la película de las antiguas cámaras de fotos. Así, la imagen negativa contiene la misma información sobre las células cerebrales que la imagen positiva correspondiente, pero gracias a que el procedimiento de etiquetado es más simple, es mucho más fácil de obtener esta imagen y toda la información que contiene.


Según el Dr. Tønnesen "La técnica SUSHI es revolucionaria porque nos permite visualizar simultáneamente todas las células cerebrales en una región determinada del tejido cerebral vivo. Antes encontrábamos espacios en blanco en las imágenes de microscopía, ya que no podíamos etiquetar todas las células al mismo tiempo. Este hecho nos resultaba muy limitante. Desde ahora, con esta técnica podremos ver todas las células del área de estudio que situemos en la lente del microscopio, así como sus interacciones, de manera que podremos avanzar en nuestro conocimiento de las funciones el cerebrales, tanto en el órgano sano, como cuando enferma".

Este avance es fruto de un proyecto interdisciplinar y transfronterizo desarrollado entre el grupo de investigación dirigido por el Profesor Valentin Nägerl de la Universidad de Burdeos (Francia) y el Dr. Jan Tønnesen, que se incorporó al Departamento de Neurociencias de la UPV/EHU, y que trabaja en las instalaciones del ACHUCARRO, en el Parque Científico de esta universidad, en Leioa.


Referencia bibliográfica: Tønnesen J, Inavalli VVGK & Nägerl UV “Super-resolution imaging of the extracellular space in living brain tissue” Cell (Feb 22, 2018) DOI: https://doi.org/10.1016/j.cell.2018.02.007 
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The women allege that Steven and Jean Lopez sexually assaulted them. and USA Taekwondo knew about the abuse. Because many of the alleged incidents occurred abroad, the lawsuit claims that the organizations effectively engaged in sex trafficking. Chief External Affairs Officer Patrick Sandusky said. Center for SafeSport, along with a number of additional significant actions we are taking, will ensure that our athletes are better protected from these heinous acts." As NPR previously reported, Heidi Gilbert alleges that after winning a Coach Outlet Store Online gold medal in her weight class in the Pan American Games in Ecuador in 2002, Jean Lopez assaulted her in his hotel room. She says he threw her onto the bed and, at first, she thought they were wrestling. But coach outlet online then, she says, he put her in a fetal position, coach factory outlet rubbed his groin against her, and ejaculated into his pants. Meloon, who had filed a public complaint in 2006, alleges in the suit that Jean Lopez digitally penetrated her vagina when she was asleep in her hotel room in Cairo, Egypt, after she competed in the World Cup in official coach outlet online 1997. As detailed in the lawsuit, she was 15 years old at the time. Meloon was in a relationship with Steven Lopez for Coach.com several years. She says that he physically beat her on more than one occasion and raped her in 2005. Center for SafeSport, coach factory outlet online login along with a number of additional significant actions we are taking, will ensure that our athletes are better protected from these heinous acts." Neither Steven nor Jean Lopez Coach Factory Outlet Store responded to requests for comment. Staff at USA Taekwondo said they needed to review the suit before coach handbags outlet responding. There is at least one other woman who is not part of the lawsuit who also alleges Steven Lopez engaged in sexual misconduct. Nina Zampetti began training with coach factory outlet online the Lopezes when she was eight years old. She says that when she was 14, Steven who was then 22 had her perform oral sex on him. USA Taekwondo first received a formal complaint against Steven and Jean Lopez in 2006. The former head of the official coach factory outlet online organization cleared them of wrongdoing, although some members of the board found the investigation perfunctory. Center for SafeSport, a nonprofit tasked with investigating abuse across Olympic sports. The organization banned Jean Lopez last month, citing "a decades long pattern of sexual misconduct." He is appealing the decision. When Nina Zampetti looks back on her interactions with Steven Lopez, she sees how he exploited his position as her coach to allegedly sexually abuse her. Lopez could be very effusive with his praise, she coach outlet sale remembers. When she was around 11, she says, he made a grand pronouncement: "He gave me a ring and told me we would be together some day."Former USA Taekwondo Coach Banned From The Sport For Sexual Misconduct But Lopez could also be a tough taskmaster. Zampetti remembers Coach Outlet Online Store that when she was around 12 cheap coach purses years old he called for her as she was walking to a local store; she declined to run to his side. Later, as punishment, he demanded that she hold a headstand position for what she estimates was about five minutes. When he finally let her come up, she started crying uncontrollably. "I felt like I did something so terribly wrong," she recalls. "I felt so humiliated." Zampetti quit the sport the year after Steven coach factory store online Lopez allegedly had her perform oral sex on him. She found the experience deeply violating. Learning of the other alleged victims and the lawsuit, she says, was validating. "For so long I thought I was the only one," she says. Zampetti filed a police report with the Fort Bend County Sheriff in Richmond, Texas on April 30 detailing the alleged sexual encounter. SafeSport is also investigating Steven Lopez. The case has now been under review for 14 months. The Center declined to comment on the status of the investigation, which is their policy on all active queries. Ronda Sweet, who served on the board of USA Taekwondo from 2006 2010 and has been deeply coach outlet store online critical of how the organization handled allegations of sexual assault, points out that there was a financial incentive for the organization to refrain from banning coach outlet store online the brothers. The issue of sexual assault is certainly not unique to taekwondo. Swimming, gymnastics, speedskating, and figure skating have all been plagued with their own scandals. USA Taekwondo's executive director, Steve McNally, says he wants to change the culture of the sport. "USA Taekwondo is now aiming to become the example of how to click here get this right," he says. McNally assumed the position late last year. Next month, he says, the organization will unfurl an educational campaign that will describe the dynamics of a healthy coach athlete relationship. "We have to be maybe more vigilant than some other sports that don't have that master student relationship, that dominance, built into the sport," he says.
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